Research Engineer Postdoc – Bioinformatics and Data Analysis M F

  • Type Régie
  • BUDGET Tarif selon profil
  • Durée (mois) 6
  • Pays France
  • Remote NON
  • Offres0
  • Moyenne Tarif selon profil
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Publiée le 23 novembre 2024

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Description de la mission

Context: We are currently seeking a talented and motivated Bioinformatician for an exciting project funded by the European Horizon Europe aimed at advancing therapies for renal ciliopathies (https://theracil.eu). The candidate will join the lab of Dr. S. Saunier (Laboratory of Hereditary Kidney Diseases), a leader in functional studies on renal ciliopathies and the Bioinformatics platform at IMAGINE (led by P. Nitschké).

Background: Ciliopathies, a group of rare genetic diseases, result from primary cilium dysfunction and manifest in various severe disorders. These disorders, which include polycystic kidney diseases (ARPKD and ADPKD) and nephronophthisis, often lead to the progressive deterioration of renal function, resulting in late-stage renal disease. The project’s laboratory aims to enhance the diagnosis and prognosis of renal ciliopathy patients while implementing therapeutic approaches. The project involves a consortium of European partners leveraging unique databases and multi-omics data for patient stratification and identification of therapeutic targets.
Mission Objectives: The recruited professional will analyze and integrate « omics » data, including WGS, RNA-Seq, and proteomics from patient cells, kidney organoids, and mouse models. Key tasks include analyzing scRNASeq and snRNASeq data to assess the impact of therapeutic interventions, identify target cell populations, and evaluate single-cell responses and immune cell involvement. The candidate will work closely with biologists and other bioinformaticians involved in the consortium.

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